Bisoprololum Index Natura Bisoprololi | Notae | Nexus interniTabula navigationisWHO"Pharmacokinetics and metabolism of bisoprolol enantiomers in humans"

Ordinis mundi sanitarii medicamenta principaliaAntiarrhythmica


antiarrhythmicumordinis mundi sanitariiindicem exemplarem medicamentorum principaliumbeta1-receptoriorumRSCodex ATCC07AB07Tempus semivitae biologicumCytochromatis P450 CYP2D6CYP3A4CYP3A4







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Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.


Bisoprololum est substantia chemica beta-receptoria typi primi inhibens et propterea medicamentum antihypertensivum velut antiarrhythmicum classis II est.


Bisoprololum in ordinis mundi sanitarii indicem exemplarem medicamentorum principalium receptum est.




Index





  • 1 Natura Bisoprololi

    • 1.1 Natura chemica


    • 1.2 Natura pharmacologica


    • 1.3 Pharmacocinetica


    • 1.4 Interactiones



  • 2 Notae


  • 3 Nexus interni




Natura Bisoprololi |



Natura chemica |





Bisoprololum beta1-receptoria valde selective inhibet.


Bisoprololum est beta1-receptoriorum inhibitor. Structura eius chemica est (RS)-1-[4-(2-isopropoxyethoxymethyl)phenoxy]-3-isopropylamino-2-propanolum.


Formula chemica est C18H31NO4, massa molaris 325.45 g/mol.
Codex ATC est C07AB07 (WHO).



Natura pharmacologica |



Pharmacocinetica |


Solubilitas in aqua est 2.24 g·mol−1 (25 °C), accessibilitas biologica 90%.
Tempus semivitae biologicum t12displaystyle t_frac 12.[1]10 – 12 h est.


Bisoprololum substratum et Cytochromatis P450 CYP2D6 ( (R)-(+)-bisoprololum > (S)-(-)-bisoprololum ) et CYP3A4 ( (R)=(S) ) est.[2]



Interactiones |


Cum Bisoprololum subtratum enzymi CYP3A4 esset, inhibitores CYP3A4 effectus Bisoprololi augere possint, inductores invicem diminuere, per exemplum:







Pharmaca cum effectibus Bisoprololi substrati
Inhibitores cum Bisoprololi effectibus fortioribus
Inductores cum Bisoprololi effectibus minoribus

  • Antihypertensiva

    • Calcii canalium inhibitores
      • Diltiazemum

      • Felodipinum



  • Antiarrhythmica
    • Amiodaronum

  • Diuretica/Hormonta

    • Conivaptanum (forte)


  • Antibiotica
    • Ciprofloxacinum


    • Clarithromycinum (forte)


    • Erythromycinum (forte)


    • Telithromycinum (forte)


  • Fungicida/-statica

    • Ketoconazolum (forte)


    • Itraconazolum (forte)


    • Posaconazolum (forte)


    • Voriconazolum (forte)


  • Proteasis inhibitores
    • Atazanavirum-Ritonavirum


    • Boceprevirum (forte)


    • Ritonavirum (forte)


    • Indinavirum (forte)


    • Nelfinavirum (forte)


    • Saquinavirum (forte)


    • Telaprevirum (forte)


  • Antidepressiva

    • Nefazodonum (forte)

  • Glucocorticoides

    • Dexamethasonum (forte)


  • Hormonta
    • GH


  • Plantae
    • Fructus averrhoae carambolae

    • Silybum marianum



  • Anticonvulsiva

    • Carbamazepinum (forte, quoque P-gp)


    • Phenytoinum (forte)


    • Fosphenytoinum (forte)


    • Oxcarbazepinum (forte)

    • Topiramatum


    • Phenobarbitalum (forte)


    • Primidonum (forte)


  • Antidepressiva

    • Hypericum perforatum (forte, quoque P-gp)

  • Antihypertensiva

    • Bosentanum (forte, endothelini receptoris inhibitor)

  • Substantiae antiretrovirales

    • Efavirenzum (forte)


    • Etravirinum (forte)


    • Nevirapinum (forte)


  • Substantiae antineoplasticae
    • Enzalutamidum


    • Mitotanum (forte)



  • Antibiotica

    • Rifabutinum (forte)


    • Rifapentinum (forte)


    • Nafcillinum (forte)


    • Rifampicinum (forte)



  • Hormonta
    • Triiodthyroninum (T3)

  • Modafinilum

  • Quercetinum

  • Capsaicinum


Notae |



  1. ↑ http://goldbook.iupac.org/B00658.html


  2. ↑ Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences 87 (3): 289–294 


Nexus interni


  • Cor

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