Doxepinum Nexus interni Notae | Tabula navigationis3158DB01142WHOa682390"Structural Analysis of the Histamine H1 Receptor""Transdermal and Topical Drug Administration in the Treatment of Pain""Antidepressants as antipruritic agents: A review"

Antidepressiva


depressionuminsomniareceptorium H1agonista inversapruritusdermatitis atopicaelichenis simplicis chronici (neurodermatitis)







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Doxepinum

Doxepinum

Doxepinum
Natura chemica
Formula chemicaC19H21NO
Massa molaris279.376 g/mol
PubChem
3158
DrugBank
DB01142
Natura pharmacologica
Codex ATC
N06AA12 (WHO)
Tempus semivitae biologicum17 (8-24) h
Nor-Doxepinum: 31 h
Metabolismus
iecore (hepaticus):
CYP2D6
CYP2C19
MetabolitusNor-Doxepinum
Excretio
renibus (ca. 50%), faecibus: minus
Ad usum therapeuticum
Applicatioper os, i.v., i.m.
MedlinePlus
a682390 .mw-parser-output .existinglinksgray a,.mw-parser-output .existinglinksgray a:visitedcolor:gray.mw-parser-output .existinglinksgray a.newcolor:#ba0000.mw-parser-output .existinglinksgray a.new:visitedcolor:#a55858
(Anglice)

Doxepinum est substantia psychoanaleptica et antidepressiva, ergo medicamentum tractationis depressionum, praesertim cum insomnia praesente, effectu sedativo suo causa, quia Doxepinum receptorium H1 agonista inversa[1] obsidet. Per structuram chemicam Doxepinum est antidepressivum tricyclicum. Ceroma[2] quoque Doxepinum therapiae pruritus[3] et dermatitis atopicae et lichenis simplicis chronici (neurodermatitis) brevis temporis adhiberi potest.


Nexus interni


  • Depressio

  • Dermatologia

  • Intervallum QT


Notae |



  1. ↑ Shiroishi M, Kobayashi T (2017). "Structural Analysis of the Histamine H1 Receptor". Handb Exp Pharmacol 241: 21-30 


  2. ↑ Leppert W, Malec-Milewska M, Zajaczkowska R, Wordliczek J (2018). "Transdermal and Topical Drug Administration in the Treatment of Pain". Molecules 23 (3): pii:E681 


  3. ↑ Kaur R, Sinha VR (2018). "Antidepressants as antipruritic agents: A review". Eur Neuropsychopharmacol 28 (3): 341-52 








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